Ⅷ-1 |
片頭痛は遺伝するか,また片頭痛に関与している遺伝子にはどのようなものがあるか
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論文抄録 |
OBJECTIVE--To investigate familial occurrence of migraine with and without aura. DESIGN--Familial occurrence of migraine with and without aura among first degree relatives and spouses of probands with migraine with or without aura and those who had never had migraine. All interviews of first degree relatives and spouses were done blindly by a neurological resident. The operational diagnostic criteria of the International Headache Society were used. SETTING--General population from Copenhagen County . SUBJECTS--The 378 probands had 1109 first degree relatives and 229 spouses. MAIN OUTCOME MEASURES--Patterns of familial aggregation of migraine with and without aura as assessed by calculation of the population relative risk. RESULTS--Compared with the general population the first degree relatives of probands with migraine without aura had 1.9 times the risk of migraine without aura and 1.4 times the risk of migraine with aura. The first degree relatives of probands with migraine with aura had nearly four times the risk of migraine with aura and no increased risk of migraine without aura. The first degree relatives of probands who had never had migraine had no increased risk of migraine either with or without aura. Spouses of probands with migraine without aura had 1.4 times the risk of migraine without aura whereas spouses of probands with migraine with aura had no increased risk of migraine with aura. CONCLUSION--The different familial patterns indicate that migraine without aura and migraine with aura have a different aetiology. Migraine without aura seems to be caused by a combination of genetic and environmental factors whereas migraine with aura is probably determined largely or exclusively by genetic factors. |
文献 PubMed-ID |
PMID: 7663209 |
エビデンスレベル |
VI |
文献タイトル (日本語) |
片頭痛における高い家族性リスクと遺伝因子の証拠 |
目的 |
前兆のある,またはない片頭痛の家族内発症について検討する |
研究デザイン |
横断研究 |
研究施設 |
Department of Neurology, Glostrup Hospital , University of Copenhagen , Denmark . |
対象患者 |
378名の発端者と1109名の第一度近親者,229名の配偶者 |
介入 |
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主要評価項目とそれに用いた 統計学的手法 |
Probability (relative is affected | proband is affected)/ (Probability (random member of the population affected))の算出 |
結果 |
Compared with the general population the first degree relatives of probands with migraine without aura had 1.9 times the risk of migraine without aura and 1.4 times the risk of migraine with aura. The first degree relatives of probands with migraine with aura had nearly four times the risk of migraine with aura and no increased risk of migraine without aura. The first degree relatives of probands who had never had migraine had no increased risk of migraine either with or without aura. Spouses of probands with migraine without aura had 1.4 times the risk of migraine without aura whereas spouses of probands with migraine with aura had no increased risk of migraine with aura. |
結論 |
前兆のある片頭痛と前兆のない片頭痛とでは家族の発症者のパターンが異なっており,両者における発症機序が異なることが推察される. 前兆のない片頭痛は遺伝因子と環境因子が重なって発症するのに対し,前兆のある片頭痛は遺伝因子の関与が非常に大きいことが予測される. |
コメント |
Danish Central Person Registryというコホート集団の40歳の男性3000人,女性1000人において,第一度近親者や配偶者にも直接インタヴューを試みている.λs は前兆のある片頭痛では3.35,前兆のない片頭痛で1.95という結果が得られている.しかし,probandの男女比(男:女=3:1)に差がありすぎる点は問題と思われる. |
備考 |
MeSH Terms: Adolescent Adult Aged Child Child, Preschool Denmark/epidemiology Female Human Infant Infant, Newborn Male Middle Aged Migraine/epidemiology Migraine/etiology Migraine/genetics* Pedigree Prevalence Risk Factors Support, Non-U.S. Gov't |
作成者 |
百瀬義雄 |