頭痛研究のトピックス

2010年5月29日

日本頭痛学会会員各位

この度、広報委員会で討議した結果、頭痛診療に役立つ臨床的な研究報告、または頭痛診療に関連のある疼痛学の基礎的な研究成果を掲載した最近の論文内容を紹介するコーナーをホームページに新設することとなりました。
本ホームページを利用される皆様にご活用頂ければ幸いです。これまでにない試みなので、皆様からのご意見をもとに、より良い形で運営していければと思っております。

慶應義塾大学神経内科
企画広報委員
柴田 護

反復性片頭痛患者に対するエレヌマブ早期投与と非特異的経口片頭痛予防薬の比較
Pozo-Rosich P, et al. Early Use of Erenumab vs Nonspecific Oral Migraine Preventives: The APPRAISE Randomized Clinical Trial. JAMA Neurol 2024 Mar 25:e240368.
掲載日:2024/05/07

視床下部オキシトシン陽性ニューロンによる三叉神経頸髄複合体広作動域ニューロン抑制効果
Condés-Lara M, et al. Hypothalamic paraventricular stimulation inhibits nociceptive WDR trigeminocervical complex cells via oxytocinergic transmission. J Neurosci. 2024 Mar 4:e1501232024. doi: 10.1523/JNEUROSCI.1501-23.2024.
掲載日:2024/03/26

片頭痛に関連したスティグマと生活支障度や生活の質との関係
Shapiro RE, et al. Migraine-related stigma and its relationship to disability, interictal burden, and quality of life. Neurology 2024;102:e208074.
掲載日:2024/03/26

皮質拡延性脱分極/抑制による硬膜三叉神経の感作についての新知見
Blaeser AS, et al. Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model. Elife 2023;12:RP91871.
掲載日:2024/02/19

反復性片頭痛成人患者における日常的なカフェイン飲料摂取と頭痛の関連性
Mittleman MR, et al. Habitual caffeinated beverage consumption and headaches among adults with episodic migraine: A prospective cohort study. Headache. 2024 Feb 6. doi: 10.1111/head.14673. Online ahead of print.
掲載日:2024/02/19

片頭痛予兆時の Ubrogepant 投与による頭痛発生に対する抑制効果
Dodick DW, et al. Ubrogepant for the treatment of migraine attacks during the prodrome: a phase 3, multicentre, randomised, double-blind, placebo-controlled, crossover trial in the USA. Lancet. 2023 Nov 15:S0140-6736(23)01683-5. doi: 10.1016/S0140-6736(23)01683-5.
掲載日:2023/12/06

稀であるが影響力の大きい遺伝子バリアントがもたらした片頭痛病型の遺伝的背景に関する新知見
Bjornsdottir G, et al. Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura. Nat Genet. 2023 Oct 26. doi: 10.1038/s41588-023-01538-0.
掲載日:2023/11/13

貨幣状頭痛の長期経過: 168 名の患者追跡調査
García-Iglesias C, et al. Long-term outcomes of nummular headache: A series of 168 patients and 1198 patient-years of follow-up. Cephalalgia. 2023 Sep;43(9):3331024231201576. doi: 10.1177/03331024231201576.
掲載日:2023/10/19

Atogepant の慢性片頭痛に対する第3相臨床試験(PROGRESS)
Pozo-Rosich P, et al. Atogepant for the preventive treatment of chronic migraine (PROGRESS): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2023 Jul 26:S0140-6736(23)01049-8. doi: 10.1016/S0140-6736(23)01049-8.
掲載日:2023/08/17

抗PACAP抗体LuAG09222のPACAP38誘発性血管拡張作用に対する阻害効果
Rasmussen NB, et al. The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional,randomized, double-blind, parallel-group, placebo-controlled study. J Headache Pain 2023;24:60.
掲載日:2023/07/20

片麻痺性片頭痛に対するCGRP関連抗体薬の効果
Danno D, et al. Treatment of hemiplegic migraine with anti-calcitonin gen-related peptide monoclonal antibodies: A case series in a tertiary care headache center.
Headache. 2023 Jun 27. doi: 10.1111/head.14591.
掲載日:2023/07/20

CGRP 関連抗体薬が慢性片頭痛患者の血清 CGRP 濃度に与える影響
Gárate G, et al. Serum Alpha and Beta-CGRP Levels in Chronic Migraine Patients Before and After Monoclonal Antibodies Against CGRP or its Receptor.
Ann Neurol. 2023 Apr 11. doi: 10.1002/ana.26658.
掲載日:2023/05/02

IT 企業で施行された 7 万人を対象にした頭痛疫学調査と治療介入効果
Sakai F, et al. Diagnosis, knowledge, perception, and productivity impact of headache education and clinical evaluation program in the workplace at an information technology company of more than 70,000 employees.
Cephalalgia. 2023 Apr;43(4):3331024231165682. doi: 10.1177/03331024231165682.
掲載日:2023/04/13

片頭痛非発作期の頭部アロディニアの有無によるガルカネズマブ有効性予測
Ashina S, et al. Pre-treatment non-ictal cephalic allodynia identifies responders to prophylactic treatment of chronic and episodic migraine patients with galcanezumab: A prospective quantitative sensory testing study (NCT04271202). Cephalalgia.
2023 Mar;43(3):3331024221147881. doi: 10.1177/03331024221147881.
掲載日:2023/03/03

小児・若年成人期の頭頚部 CT 検査による放射線被曝後の悪性脳腫瘍発症について
Hauptmann M, et al. Brain cancer after radiation exposure from CT examinations of children and young adults: results from the EPI-CT cohort study. Lancet Oncol
2023; 24:45-53.
掲載日:2023/02/22

片頭痛患者の髄液で認められた L-アルギニン減少: 中枢での NO 産生亢進の可能性
Onderwater GLJ, et al. Cerebrospinal fluid and plasma amine profiles in interictal migraine. Ann Neurol.
2022 Dec 13. doi: 10.1002/ana.26576.
掲載日:2023/01/10

テストステロンのTRPM8を介する抗片頭痛作用
Alarcon-Alarcon D, et al. TRPM8 contributes to sex dimorphism by promoting recovery of
normal sensitivity in a mouse model of chronic migraine. Nat Commun
2022;13:6304.
掲載日:2022/11/22

唾液中CGRP濃度とエレヌマブへの治療反応性との関連性
Alpuente A, et al. Salivary CGRP and Erenumab Treatment Response: Towards Precision
Medicine in Migraine. Ann Neurol.
2022 Aug 7. doi: 10.1002/ana.26472.
掲載日:2022/10/13

Ubrogepant は片頭痛発作が軽度なタイミングで投与すべき
Lipton RB, et al. Efficacy of ubrogepant in the acute treatment of migraine with mild pain
versus moderate or severe pain. Neurology.
2022 Aug 17;10.1212/WNL.0000000000201031. doi: 10.1212/WNL.0000000000201031.
掲載日:2022/09/06

複数の既存予防薬で治療が奏功しなかった片頭痛に対するeptinezumabの有効性と安全性
Ashina M, et al. Safety and efficacy of eptinezumab for migraine prevention in patients
with two-to-four previous preventive treatment failures (DELIVER): a multi-arm,
randomised, double-blind, placebo-controlled, phase 3b trial. Lancet Neurol
2022;21:597-607.br> 掲載日:2022/07/21

ヒトとマウスにおける三叉神経節の細胞構成と遺伝子発現:片頭痛病態との関連性
Yang L, et al. Human and mouse trigeminal ganglia cell atlas implicates multiple cell types
in migraine. Neuron 2022;110:1806-1821.
掲載日:2022/06/23

ガルカネズマブが片頭痛患者の後頭葉機能に与える影響
de Tommaso M, et al. Central effects of galcanezumab in migraine:
a pilot study on Steady State Visual Evoked Potentials and occipital hemodynamic response
in migraine patients. J Headache Pain 2022;23:52.
掲載日:2022/05/24

プロラクチンを介した視床下部による硬膜侵害受容器活性化機構
Watanabe M, et al. Dysregulation of serum prolactin links the hypothalamus with female
nociceptors to promote migraine. Brain. 2022 Mar 24;awac104. doi:
10.1093/brain/awac104.
掲載日:2022/04/14

片頭痛発症リスクに関与する123個の遺伝子座の判明
Hautakangas H, et al. Genome-wide analysis of 102,084 migraine cases identifies 123
risk loci and subtype-specific risk alleles. Nat Genet 2022 Feb 3. doi: 10.1038/s41588-
021-00990-0.
掲載日:2022/02/14

前兆の既往のある片頭痛とない片頭痛に対するエレヌマブの有効性と安全性の比較
Ashina M, et al. Assessment of Erenumab safety and efficacy in patients with migraine
with and without aura: A secondary analysis of randomized clinical trials. JAMA Neurol
. 2021 Dec 20. doi: 10.1001/jamaneurol.2021.4678.
掲載日:2022/01/06

降雪視症候群に認められる視覚入力に対するコントラストゲインの異常
Brooks CJ, et al. Visual contrast perception in visual snow syndrome reveals abnormal neural gain but not neural
noise. Brain 2021 Oct 11;awab383. doi: 10.1093/brain/awab383.
掲載日:2021/11/04

Atogepantによる片頭痛予防効果
Ailani J, et al. Atogepant for the Preventive Treatment of Migraine. N Engl J Med
2021;385:695-706.
掲載日:2021/9/03

2つのGWAS による群発頭痛患者疾患リスク遺伝子座の同定
1. Harder AVE, et al. Genetic susceptibility loci in genome-wide association study of cluster headache. Ann Neurol 2021 Jun 28. doi: 10.1002/ana.26146.
2. O' Connor E, et al. Genome wide association study identifies risk loci for cluster headache. Ann Neurol 2021 Jun 29. doi: 10.1002/ana.26150.
掲載日:2021/7/27

片頭痛発作中の eptinezumab 投与による治療効果の検討
Winner PK, et al. Effects of intravenous eptinezumab vs placebo on headache pain and most bothersome symptom when initiated during a migraine attack: A randomized clinical trial. JAMA. 2021;325:2348-2356.
掲載日:2021/7/2

マウス慢性片頭痛および外傷後頭痛モデルにおけるCGRPとPACAP反応性三叉神経節ニューロンの増加
Guo Z, et al. Increase in trigeminal ganglion neurons that respond to both calcitonin gene-related peptide and pituitary adenylate cyclase-activating polypeptide in mouse models of chronic migraine and posttraumatic headache. Pain 2021;162:1483-1499.
掲載日:2021/5/26

硬膜におけるプロラクチンと CGRP の相互作用の片頭痛病態への関与
Avona A, et al. Meningeal CGRP-Prolactin interaction evokes female-specific migraine behavior. Ann Neurol 2021 Mar 22. doi: 10.1002/ana.26070.
掲載日:2021/4/6

硬膜支配三叉神経節ニューロンによる結合腕傍核への直接入力
Uddin O, et al. Parabrachial complex processes dura inputs through a direct trigeminal ganglion to parabrachial connection. Neurobiol Pain 2021 1000060.
掲載日:2021/2/19

Rimegepantによる片頭痛予防効果を検討した第 2/3 相臨床試験
Croop R, et al. Oral rimegepant for preventive treatment of migraine: a phase 2/3, randomised, double-blind, placebo-controlled trial. Lancet 2021;397:51-60.
掲載日:2021/1/18

Visual snow syndrome患者に認められた特異なSPECT所見
Shibata M, et al. [123 I]-IMP single-photon emission computed tomography imaging in visual snow syndrome: A case series. Cephalalgia 2020;40:1671-1675.
掲載日:2020/12/24

反復性群発頭痛患者に対するプレドニゾンの効果と安全性
Obermann M, et al. Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial. Lancet Neurol 2020 Nov 24;S1474-4422(20)30363-X. doi: 10.1016/S1474-4422(20)30363-X.
掲載日:2020/12/24

既存の予防薬での治療困難片頭痛症例に対するgalcanezumabの効果と安全性
Mulleners WM, et al. Safety and efficacy of galcanezumab in patients for whom previous migraine preventive medication from two to four categories had failed (CONQUER): a multicentre, randomised, double blind, placebo controlled, phase 3b trial. Lancet Neurol 2020;19:814 825.
掲載日:2020/10/07

Atogepantによる片頭痛予防効果を検討した臨床試験
Goadsby PJ, et al. Safety, tolerability, and efficacy of orally administered atogepant for the prevention of episodic migraine in adults: a double-blind, randomized phase 2b/3 trial. Lancet Neurol 2020;19:727-737.
掲載日:2020/09/11

片頭痛患者身体活動の客観的計測
Rogers DG, et al. Objectively measured physical activity in migraine as a function of headache activity.
Headache 2020 doi: 10.1111/head.13921
掲載日:2020/08/24

閉鎖性頭部外傷の重症化や繰り返す脳震盪がラットの頭部外傷モデルにおいて受傷後の頭痛様行動を増幅する
Bree D, et al. Increased severity of closed head injury or repetitive subconcussive head impacts enhances post-traumatic headache-like behaviors in a rat model
Cephalalgia 2020, DOI: 10.1177/0333102420937664
掲載日:2020/07/15

薬剤の使用過多による頭痛に対する3つの治療法の比較
Carlsen LN, et al. Comparison of 3 Treatment Strategies for Medication Overuse Headache: A Randomized Clinical Trial. JAMA Neurol. 2020 May 26;e201179. doi: 10.1001/jamaneurol.2020.1179.
掲載日:2020/06/23

頭痛治療薬とCOVID-19パンデミック
MaassenVanDenBrink A, et al. Headache medication and the COVID-19 pandemic. J Headache Pain 2020;21:38.
掲載日:2020/05/14

Visual snow syndrome患者に認められる脳の構造的および機能的変化
Schankin CJ, et al. Structural and functional footprint of visual snow syndrome. Brain 2020;143:1106-1113.
掲載日:2020/05/14

キアリ1型奇形による咳嗽性頭痛の予測における2次元解剖学的測定の臨床的有用性
Huang CWC, et al. Clinical utility of 2-D anatomic measurements in predicting cough-associated headache in Chiari I malformation
Neuroradiology 2020, DOI: 10.1007/s00234-019-02356-0
掲載日:2020/03/24

7名の片頭痛患者を30日間にわたり連日記録したfunctional MRIデータ
Schulte LH, et al. Longitudinal neuroimaging over 30 days: Temporal characteristics of migraine. Ann Neurol. doi: 10.1002/ana.25697.
掲載日:2020/02/27

TRPM8発現低下は片頭痛リスク減少と寒冷疼痛減弱を引き起こす
Gavva NR, et al. Reduced TRPM8 expression underpins reduced migraine risk and attenuated cold pain sensation in humans. Sci Rep 2019;9:19655.
掲載日:2020/01/21

片頭痛急性期におけるubrogepantの頭痛と最も煩わしい随伴症状に対する効果
Lipton RB, et al. Effect of ubrogepant vs placebo on pain and the most bothersome associated symptom in the acute treatment of migraine: The ACHIEVE II randomized clinical trial. JAMA 2019;322:1887-1898.
掲載日:2019/12/06

治療抵抗性片頭痛症例に対するFremanezumabの片頭痛予防効果
Ferrari M, et al. Fremanezumab versus placebo for migraine prevention in patients with documented failure to up to four migraine preventive medication classes (FOCUS): a randomized, double-blind, placebo-controlled, phase 3b trial. Lancet 2019;394:1030-1040.
掲載日:2019/11/01

皮質拡延性抑制によって誘発される硬膜および軟膜血管の変化と抗CGRP抗体投与の影響
Schain AJ, et al. CSD-induced arterial dilatation and plasma protein extravasation are unaffected by fremanezumab: Implications for CGRP’s role in migraine with aura. J Neurosci 2019;39:6001-6011.
掲載日:2019/09/24

CGRP受容体拮抗薬rimegepantによる片頭痛治療効果
Lipton RB, et al. Rimegepant, an oral calcitonin gene-related peptide receptor antagonist, for migraine. N Engl J Med 2019;381:142-149.
掲載日:2019/08/02

抗CGRP抗体Eptinezumabによる慢性片頭痛の予防効果
Dodick DW, et al. Eptinezumab for prevention of chronic migraine: A randomized phase 2b clinical trial. Cephalalgia 2019 Jun 24:333102419858355. doi: 10.1177/0333102419858355.
掲載日:2019/07/09

Lasmiditanの片頭痛急性期治療薬としての薬効と安全性を評価した第3相試験の結果
Goadsby PJ, et al. Phase 3 randomized, placebo-controlled, double-blind study of lasmiditan for acute treatment of migraine. Brain 2019 May 27. pii: awz134. doi: 10.1093/brain/awz134.
掲載日:2019/06/14

片頭痛における視床―大脳皮質ネットワーク動態の異常
Tu Y, et al. Abnormal thalamo-cortical network dynamics in migraine. Neurology 2019;92:e1-e11. doi: 10.1212/WNL.0000000000007607.
掲載日:2019/06/14

前兆のある片頭痛患者における神経炎症の関与
Albrecht DS, et al. Imaging of neuroinflammation in migraine with aura. A [11C]PBR28 PET/MRI study. Neurology 2019;92:e1-e3.
掲載日:2019/04/15

前庭性片頭痛患者に認められる視覚系と前庭系の相互作用の異常
Bednarczuk NF, et al. Abnormal visuo-vestibular interactions in vestibular migraine: a cross sectional study. Brain 2019 Feb 12. doi: 10.1093/brain/awy355.
掲載日:2019/03/04

片頭痛がstroke mimicsになるとき:システマティックレビュー
Terrin A, et al. When migraine mimics stroke: A systematic review Cephalalgia 2018; 38: 2068-2078
掲載日:2019/02/04

片頭痛発生における硬膜の関与を示唆するMRA所見
Khan S, et al. Meningeal contribution to migraine pain: a magnetic resonance angiography study. Brain 2019;142:93-102.
掲載日:2019/01/21

複数の予防薬で治療が奏功しなかった片頭痛に対するErenumabの効果と忍容性
Reuter U, et al. Efficacy and tolerability of erenumab in patients with episodic migraine in whom two-to-four previous preventive treatments were unsuccessful: a randomized, double-blind, placebo-controlled, phase 3b study. Lancet 2018. doi: 10.1016/S0140-6736(18)32534-0.
掲載日:2018/12/10

クライオ電子顕微鏡によるCGRP受容体構造の解明
Liang Y-L, et al. Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor. Nature 2018;561:492-499.
掲載日:2018/10/17

片頭痛患者の頭痛を認めない日における機能性に対するFremanezumabの影響
VanderPluym J, et al. Fremanezumab for preventive treatment of migraine. Functional status in headache-free days. Neurology 2018. pii: 10.1212/01.wnl.0000544321.19316.40. doi: 10.1212/01.wnl.0000544321.19316.40.
掲載日:2018/09/11

一酸化窒素供与体による頭痛の発生機序における三叉神経節ニューロンTRPA1の役割
Marone IM, et al. TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice. Brain 2018 doi: 10.1093/brain/awy177.
掲載日:2018/08/01

片頭痛急性期治療としての非侵襲的迷走神経刺激術
Tassorelli C, et al. Noninvasive vagus nerve stimulation as acute therapy for migraine. Neurology 2018 doi: 10.1212/WNL.0000000000005857.
掲載日:2018/07/04

慢性片頭痛患者における視覚刺激後の三叉神経脊髄路核の活性化
Schulte LH, et al. Visual stimulation leads to activation of the nociceptive trigeminal nucleus in chronic migraine. Neurology DOI 10.1212/WNL.0000000000005622
掲載日:2018/06/06

マウスにおけるカフェインの皮質拡延性脱分極に対する影響
Yalcin N, et al. Caffeine does not affect susceptibility to cortical spreading depolarization in mice. J Cereb Blood Flow Metab DOI: 10.1177/0271678X18768955
掲載日:2018/05/08

非外傷性くも膜下出血に伴う頭痛の特徴
Grory BM, et al. Distinguishing Characteristics of Headache in Nontraumatic Subarachnoid Hemorrhage Headache 2018; 58:364-370
掲載日:2018/04/17

デンマークで行われた片頭痛の心血管病リスクに関する人口ベースでのコホート研究
Adelborg K, et al. Migraine and risk of cardiovascular diseases: Danish population based matched cohort study. BMJ 2018;360:k96.
掲載日:2018/03/23

皮質拡延性抑制による軟膜および硬膜マクロファージと樹状細胞の活性化
Schain AJ, et al. Activation of pial and dural macrophages and dendritic cells by CSD. Ann Neurol 2018 Feb 2. doi: 10.1002/ana.25169. [Epub ahead of print]
掲載日:2018/03/01

小児救急における頭痛:5年間の後向き調査
Rossi R, et al. Headache in the pediatric emergency department: A 5-year retrospective study. Cephalalgia(2017) DOI: 10.1177/0333102417748907
掲載日:2018/02/07

反復性および慢性群発頭痛急性期治療としての非侵襲的迷走神経刺激術
Goadsby PJ, et al. Non-invasive vagus nerve stimulation for the acute treatment of episodic and chronic cluster headache: a randomized, double-blind, sham-controlled ACT2 study. Cephalalgia(2017) DOI: 10.1177/0333102417744362
掲載日:2018/01/30

Fremanezumabによる慢性片頭痛予防治療効果
Silberstein SD, et al. Fremanezumab for the preventive treatment of chronic migraine. N Engl J Med 2017;377:2123-2122.
掲載日:2017/12/07

Erenumabの反復性片頭痛に対する臨床試験
Goadsby PJ, et al. A controlled trial of erenumab for episodic migraine. N Engl J Med 2017;377:2123-2132.
掲載日:2017/12/07

非急性頭痛の治療における遠隔診療:前向き非盲検非劣性無作為化臨床試験
Muller KI, et al. Telemedicine in the management of non-acute headaches: A prospective, open-labelled non-inferiority, randomised clinical trial. Cephalalgia 2017; 37:855-863
掲載日:2017/11/06

片頭痛と脳卒中との関連性を双生児レジストリーで検証した大規模研究
Lantz M, et al. Migraine and risk of stroke: a national population-based twin study. Brain 2017;140:2653-2662.
掲載日:2017/10/31

抗CGRP抗体は三叉神経脊髄路核ニューロンにどのような影響を与えるのか?
Melo-Carrillo A, et al. Selective inhibition of trigeminovascular neurons by Fremanezumab: A humanized monoclonal anti-CGRP antibody. J Neurosci 2017;37:7149-7163.
掲載日:2017/09/28

片頭痛患者大脳皮質のグルタミン酸濃度
Zielman R, et al. Cortical glutamate in migraine. Brain 2017;140:1859-1871.
掲載日:2017/07/19

Erenumab (AMG 334)の慢性片頭痛患者に対する予防効果と安全性
Tepper S, et al. Safety and efficacy of erenumab for preventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol 2017;16:425-434.
掲載日:2017/06/05

前兆のある片頭痛の発作中における脳幹血流と血液脳関門透過性の変化
Hougaard A, et al. Increased brainstem perfusion, but no blood-brain barrier disruption, during attacks of migraine with aura. Brain 2017. doi:10.1093/brain/awx089
掲載日:2017/05/16

片頭痛発作とアロディニアの間に生じているドパミン受容体D2/D3機能の変化
DaSilva AF, et al. Dopamine D2/D3 imbalance during migraine attack and allodynia in vivo. Neurology 2017;88:1-8. 10.1212/WNL.0000000000003861
掲載日:2017/05/16

可逆性脳血管攣縮症候群における血液脳関門の破綻:病態生理と診断への関与
Lee MJ, et al. Blood-brain barrier breakdown in reversible cerebral vasoconstriction syndrome: Implications for pathophysiology and diagnosis
Ann Neurol 2017; 81:454-466
掲載日:2017/04/26

群発頭痛の症状や発作発生時間の性差に関する研究
Lund N, et al. Chronobiology differs between men and women with cluster headache, clinical phenotype does not. Neurology 2017;88:1069-1076.
掲載日:2017/03/28

においによって誘発される頭痛は片頭痛と片頭痛以外の一次性頭痛の鑑別要因になるか?
Silva-Neto RP, et al. May headache triggered by odors be regarded as a differentiating factor between migraine and other primary headaches? Cephalalgia 2017; 37:20-28
掲載日:2017/03/13

CGRPによる片頭痛様光過敏の誘発には末梢性と中枢性の別個の機構が存在する
Mason BN, et al. Induction of migraine-like photophobic behavior in mice by both peripheral and central CGRP mechanisms. J Neurosci 2017;37:204-216.
掲載日:2017/02/27

CGRPとPACAP38による片頭痛予兆症状の誘発
Guo S, et al. Premonitory and nonheadache symptoms induced by CGRP and PACAP38 in patients with migraine. Pain 2016;157:2773-2781.
掲載日:2017/02/06

片頭痛患者の31日間にわたるfunctional MRI所見の連日記録
Schulte LH, et al. The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks. Brain 2016;139:1987-1993.
掲載日:2016/12/13

小児片頭痛患者に対するアミトリプチリンとトピラマートによる発作予防効果
Powers SW, et al. Trial of amitriptyline, topiramate, and placebo for pediatric migraine. N Engl J Med 2016 DOI: 10.1056/NEJMoa1610384
掲載日:2016/12/01

自然発生片頭痛発作時における視床大脳ネットワーク活動
Coppola G, et al. Thlalamo-cortical network activity during spontaneous migraine attacks. Neurology 2016;87:2154-2160.
掲載日:2016/11/14

375,000人を対象にしたGWAS結果に基づく片頭痛疾患感受性遺伝子座の同定
Gormley P, et al. Meta-analysis of 375,000 individuals identified 38 susceptibility loci for migraine. Nat Genet 2016;doi:10.1038/hg.3598
掲載日:2016/07/21

抗CGRPモノクローナル抗体TEV-48125の投与早期における有効性
Bigal ME, et al. TEV-48125 for the preventive treatment of chronic migraine. Neurology 2016;87:1-8.
掲載日:2016/07/21

可逆性脳血管攣縮症候群患者における頭痛軽減時の血管攣縮求心性移行
Centripetal Propagation of Vasoconstriction at the Time of Headache Resolution in Patients with Reversible Cerebral Vasoconstriction Syndrome. Shimoda M, Oda S, Hirayama A, et al.
Am J Neuroradiol 2016 Published online before print April 14, 2016, doi: 10.3174/ajnr.A4768
掲載日:2016/06/30

片頭痛患者に認められる光過敏が色によって変化する神経機構の解明
Noseda R, et al. Migraine photophobia originating in cone-driven retinal pathways. Brain 2016, doi:10.1093/brain/aww119
掲載日:2016/06/09

難治性後頭神経痛に対する頸髄神経後根切断術の長期成績
Gande AV, et al. Long-term outcomes of intradural cervical dorsal root rhizotomy for refractory occipital neuralgia. J Neurosurg 2015; DOI: 10.3171/2015.6.JNS142772.
掲載日:2016/06/07

GWASデータを用いた片頭痛と冠動脈疾患の遺伝的リスクの比較検討
Winsvold BS, et al. Genetic analysis for a shared biological basis between migraine and coronary artery disease. Neurol Genet 2015;e10; doi: 10.1212/NXG.0000000000000010
掲載日:2016/05/24

抗CGRP受容体抗体AMG 334による片頭痛予防効果と安全性
Sun H, et al. Safety and efficacy of AMG 334 for prevention of episodic migraine: a randomized, double-blind, placebo-controlled, phase 2 trial. Lancet Neurol 2016. http://dx.doi.org/10.1016/S1474-4422(16)00019-3
掲載日:2016/03/16

Deep brain stimulation in headache 頭痛に対する脳深部刺激療法
Leone M and Proietti Cecchini A. Deep brain stimulation in headache.
Cephalalgia December 7, 2015 as doi:10.1177/0333102415607176.
掲載日:2016/03/04

スタチンとビタミンD併用による片頭痛予防効果の検討
Buettner C et al. Simvastatin and vitamin D for migraine prevention: a randomized controlled trial. Ann Neurol 2015;78:970-981.
掲載日:2016/01/21

TEV-48125の慢性片頭痛の予防効果
Bigal ME, et al. Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multi-centre, randomized, double-blind, placebo-controlled, phase 2b study. Lancet Neurol 2015
掲載日:2015/10/29

妊娠女性における急性頭痛の診断
Robbins MS, et al. Acute headache diagnosis in pregnant women. A hospital-based study. Neurology 2015;85:1-7.
掲載日:2015/09/08

家族性片麻痺性片頭痛1型ノックインマウスにおけるカルシウム動態とシナプス形態異常
Eikermann-Haerter, K et al. Abnormal synaptic Ca2+ homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. Ann Neurology 2015;78:193-210.
掲載日:2015/09/08

AMY1受容体の三叉神経系における発現―新しいCGRPの作用点
Walker CS, et al. A second trigeminal CGRP receptor: function and expression of the AMY1receptor. Ann Clin Transl Neurol 2015;2:595-608.
掲載日:2015/07/17

トリプタンは三叉神経脊髄路核尾側亜核と大脳皮質との機能的結合性を遮断する
Kroger IL, et al. Triptan-induced disruption of trigemino-cortical connectivity. Neurology 2015;84-1-8.
掲載日:2015/06/08

群発頭痛に対する経皮的迷走神経刺激療法の効果
Nesbitt AD, et al. Initial use of a novel noninvasive vagus nerve stimulator for cluster headache treatment. Neurology 2015;84:1249-1253.
掲載日:2015/04/24

過ぎたるは及ばざるがごとし?家族性片麻痺性片頭痛の遺伝子変異が引き起こす学習異常
Dilekoz E, et al. Migraine mutations impair hippocampal learning despite enhanced long-term potentiation. J Neurosci 2015;35:3397-3402.
掲載日:2015/03/25

月経関連片頭痛患者の三叉神経血管反応性の周期性変化に認められる異常
Ibrahimi K, et al. Reduced trigeminovascular cyclicity in patients with menstrually related migraine. Neurology 2015;84:125-131.
掲載日:2015/02/13

片頭痛メカニズムにおけるオレキシン機能異常の役割
Hoffmann J, et al. Evidence for orexinergic mechanisms in migraine. Neurobiol Dis 2014;74C:137-143. doi: 10.1016/j.nbd.2014.10.022.
掲載日:2015/01/23

片頭痛患者の脳灰白質密度の時間的変動
Coppola G, et al. Evidence for brain morphometric changes during the migraine cycle: A magnetic resonance-based morphometry study. Cephalalgia 2014; pii: 0333102414559732.
掲載日:2014/12/26

多発性硬化症治療薬ダルファンプリジンによる三叉神経痛の誘発
Birnbaum G, et al. Dalfampridine may activate latent trigeminal neuralgia in patients with multiple sclerosis. Neurology 2014;83:1610-1612.
掲載日:2014/12/02

慢性片頭痛患者の頭皮血管ではTRPV1発現が亢進している
Del Fiacco M, et al. TRPV1, CGRP and SP in scalp arteries of patents suffering from chronic migraine. J Neurol Neurosurg Psychiat 2014 Oct 6. pii: jnnp-2014-308813. doi: 10.1136/jnnp-2014-308813.
掲載日:2014/10/24

抗CGRP抗体ALD403の頻回な発作を有する片頭痛患者に対する予防効果
Dodick DW, et al. Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomized, double-blind, placebo-controlled, exploratory phase 2 trial. Lancet Neurol 2014;13:1100-1107.
掲載日:2014/10/24

抗CGRP抗体LY2951742の片頭痛予防効果を検討した第2相臨床試験の結果
Dodick DW, et al. Safety and efficacy of LY2951742, a monoclonal antibody to calcitonin gene-related peptide, for the prevention of migraine: a phase 2, randomised, double-blind, placebo-controlled study. Lancet Neurol 2014;13:885-892.
掲載日:2014/09/05

群発頭痛患者へのステロイド投与が外頸静脈血CGRP濃度とメラトニン分泌に与える影響
Neeb L, et al. Corticosteroids alter CGRP and melatonin release in cluster headache episodes. Cephalalgia 2014. pii: 0333102414539057.
掲載日:2014/08/28

前庭性片頭痛患者における視床機能異常
Russo A, et al. Abnormal thalamic function in patients with vestibular migraine. Neurology 2014;82:2120-2126.
掲載日:2014/06/24

家族性片麻痺性片頭痛1型 (S218L変異)におけるCav2.1カルシウムチャネルの機能異常
Di Guilmi MA, et al. Synaptic gain-of ?function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i. J Neurosci 2014;34:7047-7058.
掲載日:2014/06/24

片頭痛間欠期における視床下部と自律神経機能プロセシングに関わる脳部位との機能的結合性
Moulton EA, et al. Altered hypothalamic functional connectivity with autonomic circuits and the locus ceruleus in migraine. PLoS ONE 9(4): e95508. doi:10.1371/journal.pone.0095508
掲載日:2014/05/26

片頭痛急性期治療におけるバルプロ酸・メトクロプラミド・ケトロラク静注薬の薬効比較
Friedman BW, et al. Randomized trial of IV valproate vs metoclopramide vs ketorolac for acute migraine. Neurology 2014;82:976-983.
掲載日:2014/04/10

片頭痛発作の症状軽減には薬の作用と共に医師が患者に与える情報が重要?
Kam-Hansen S, et al. Altered placebo and drug labeling changes the outcome of episodic migraine attacks. Sci Transl Med 2014;6:218ra5.DOI:10.1126/scitranslmed.3006175
掲載日:2014/02/21

ニトログリセリン誘発性片頭痛発作の予兆期における脳活性化部位の検討
Maniyar FH, et al. Brain activations in the premonitory phase of nitroglycerin-triggered migraine attacks. Brain doi:10.1093/brain/awt320
掲載日:2014/01/17

18年間にわたる視覚性前兆の症状を詳細に解析した研究
Hansen JM, et al. Distinctive anatomical and physiological features of migraine with aura revealed by 18 years of recording. Brain doi:10.1093/brain/awt309

掲載日:2013/12/13

皮膚アロディニアは片頭痛慢性化の重要な予知因子である。
Louter MA, et al. Cutaneous allodynia as a predictor of migraine chronification. Brain 2013. Doi:10.1093/brain/awt251.

掲載日:2013/10/18

GWASのメタアナリシスによる片頭痛疾患感受性遺伝子座の同定
Anttila V, et al. Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet 2013;45:912-917.

掲載日:2013/08/13

小児および思春期の片頭痛患者における頭部自律神経症状の合併率
Gelfand AA, et al. Cranial autonomic symptoms in pediatric migraine are the rule, not the exception. Neurology 2013;81:431-436.

掲載日:2013/08/13

なぜストレスによって頭痛は増悪するのか?―視床下部と三叉神経脊髄路核との連絡線維とその機能
Robert C, et al. Paraventricular hypothalamic regulation of trigeminovascular mechanisms involved in headaches. J Neurosci 2013;33:8827-8840.

掲載日:2013/07/18

前兆のない片頭痛の発作時における頭蓋内および頭蓋外動脈のMRA所見
Amin FM, et al. Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study. Lancet Neurol 2013;12:454-461.

掲載日:2013/05/20

大脳皮質拡延性抑制と片頭痛発生の連続性を説明する新しいパラダイム
Karatas H, et al. Spreading depression triggers headache by activating neuronal Panx1 channels. Science 2013;339:1092-1095.

掲載日:2013/03/15

片頭痛患者における硬膜穿刺後頭痛の頻度
van Oosterhout WPJ, et al. Postdural puncture headache in migraineurs and nonheadache subjects. Neurology 2013;80:1-8.

掲載日:2013/02/19

TRPV1発現ニューロンの新規機能喪失モデルにおける表現型
Brenneis C, et al. Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing. J Neurosci 2013;33:315-326.

掲載日:2013/02/19

薬物治療抵抗性の慢性群発頭痛に対する視床下部刺激療法の長期予後
Leone M, et al. Success, failure, and putative mechanisms in hypothalamic stimulation for drug-resistant chronic cluster headache. Pain 2013;154:89-94.

掲載日:2013/01/29

アミロライド (amiloride)によるASIC1を介した抗片頭痛効果
Holland PR, et al. Acid-sensing ion channel 1: a novel therapeutic target for migraine with aura. Ann Neurol 2012;72:559-563.

掲載日:2012/12/04

PRRT2遺伝子変異は片麻痺性片頭痛の原因となる
Riant F, et al. PRRT2 mutations cause hemiplegic migraine. Neurology 2012;79:2122-2124

掲載日:2012/11/05

片頭痛患者の脳構造と疼痛プロセシングに関する男女差
Maleki N, et al. Her versus his migraine: multiple sex differences in brain function and structure. Brain 2012;135:2546-2559.

掲載日:2012/09/04

前兆のない片頭痛患者を対象にしたゲノムワイド関連研究データ
Freilinger T, et al. Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nature Genet 2012; doi:10.1038/ng.2307
掲載日:2012/07/04

慢性片頭痛に対する後頭神経刺激療法のランダム化臨床研究
Serra G, et al. Occipital nerve stimulation for chronic migraine: A randomized trial. Pain Physician 2012;15:245-253.

掲載日:2012/06/19

5-HT1F作動薬ラスミディタン経口薬の片頭痛発作に対する有効性<
Farkkila M, et al. Efficacy and tolerability of lasmiditan, an oral 5-HT1F receptor agonist, for the acute treatment of migraine: a phase 2 randomised, placebo-controlled, parallel-group, dose-ranging study. Lancet Neurol DOI:10.1016/S1474-4422(12)70047-9

掲載日:2012/05/10

群発頭痛における三叉神経侵害受容の片側性中枢性促通
Holle D, et al. Lateralized central facilitation of trigeminal nociception in cluster headache. Neurology 2012;78:985-992.

掲載日:2012/04/16

新規変異を有する家族性片麻痺性片頭痛の遷延性前兆に認められた神経血管性変化
Iizuka T, et al. Neurovascular changes in prolonged migraine aura in FHM with a novel ATP1A2 gene mutation. J Neurol Neurosurg Psychiatry 2012;83:205-212.

掲載日:2012/02/17

片頭痛患者に認められた中脳水道周囲灰白質と脳内他部位との機能的結合性の変化
Mainero C, et al. Altered functional magnetic resonance imaging resting-state connectivity in periaqueductal gray network in migraine. Ann Neurol 2011;70:838-845.

掲載日:2012/02/17

三叉神経一次ニューロンから三叉神経頸髄複合体への神経伝達の有効な抑制にはドパミンとセロトニン両者の機能が重要
Charbit AR, et al. Trigeminocervical complex responses after lesioning dopaminergic A11 nucleus are modified by dopamine and serotonin mechanisms. Pain 2011;152:2365-2376.

掲載日:2011/12/01

硬膜感受性視床ニューロンの大脳皮質への投射
Noseda R, et al. Cortical projections of functionally identified thalamic trigeminovascular neurons: Implications for migraine headache and its associated symptoms. J Neurosci 2011;31:14204-14217.

掲載日:2011/12/01

スイスで施行された30年間にわたる一次性頭痛の症状に関する縦断研究
Merikangas KR, et al. Magnitude, impact, and stability of primary headache subtypes: 30 year prospective Swiss cohort study. BMJ 2011;345:d5076doi: 10.1136/bmj.d5076.

掲載日:2011/10/28

一般集団を対象にしたゲノムワイド関連解析によって同定された3つの片頭痛疾患感受性遺伝子
Chasman DI, et al. Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Nat Genet 2011;43:695-699.

掲載日:2011/08/26

三叉神経節における侵害受容性ニューロンとsatellite glial cellとの連係プレー
Ceruti S, et al. Calcitonin gene-related peptide-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q CaV2.1 knock-in mice: Implications for basic mechanisms of migraine pain. J Neurosci 2011;31:3638-3649.

掲載日:2011/06/21

薬物乱用頭痛患者の白血球が示す遺伝子発現パターン
Hershey AD, et al. Genomic expression patterns in medication-overuse headache. Cephalalgia 2011;31:161-171.

掲載日:2011/05/10

片頭痛患者における三叉神経核の神経活動性変動
Stankewitz A, et al. Trigeminal nociceptive transmission in migraineurs predicts migraine attacks. J Neurosci

2011;31:1937-1943.

掲載日:2011/03/30

日本人の群発頭痛の臨床的特徴を多数例を用いて明らかにした研究
Imai N., et al. Clinical profile of cluster headaches in Japan: Low prevalence of chronic cluster headache, and uncoupling of sense and behavior of restlessness. Cephalalgia 2011, doi: 10.1177/0333102410391486
掲載日:2011/03/09

米国における群発頭痛に対する酸素吸入療法の実態調査

Rozen TD, Fishman RS. Inhaled oxygen and cluster headache sufferers in the United States: Use, efficacy and

economics: Results from the United States Cluster Headache Survey. Headache doi: 10.1111/j.1526-4610.2010.01806.x

掲載日:2011/02/08

くも膜下出血を示唆するハイリスクな臨床的特徴を解析した前向きコホート研究
Perry JJ, et al. High risk clinical characteristics for subarachnoid haemorrhage in patients with acute headache: prospective cohort study. BMJ 2010;341:c5204.

掲載日:2010/12/27

カリウムチャネルTRESKのドミナントネガティブ変異によって引き起こされる家族性片頭痛
Lafreniere RG, et al. A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine

 with aura. Nat Med 2010;16:1157-1161.

掲載日:2010/11/26

β遮断薬と行動療法の併用による片頭痛予防効果の検討
Holroyd KA, et al. Effect of preventive (β blocker) treatment, behavioural migraine management, or their combination

on outcomes of optimised acute treatment in frequent migraine: randomized control trial. bmj doi 2010;10.1136/c4871

掲載日:2010/11/26

片頭痛に関するゲノムワイド関連解析によって8q22.1に疾患感受性候補遺伝子の存在が明らかになった
Anttila V, et al. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.
Nat Genet 2010;42:869-873.
掲載日:2010/11/3

片頭痛と緊張型頭痛の慢性化に関する縦断研究
Ashina S, et al. Headache characteristics and chronification of migraine and tension-type headache:
A population-based study. Cephalalgia 2010;30:943-954
掲載日:2010/8/16

トリプタンは硬膜から求心線維を受ける三叉神経節ニューロンにおいてnNOS発現を上昇し、片頭痛トリガーに対する反応性を上昇させている
De Felice M., et al. Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural
afferents underlies increased responsiveness to potential migraine triggers. Brain 2010;133:2475-2488.
掲載日:2010/8/16

慢性緊張型頭痛における中枢性感作成立に関する検討
Cathcart S, et al. Noxious inhibition of temporal summation is impaired in chronic tension-type headache.
Headache 2010;50:403-412.
掲載日:2010/5/29

トピラマートの片頭痛予防効果と前兆発生抑制効果についての研究
Reuter U, et al. Migraines with and without aura and their response to preventive therapy with topiramate.
Cephalalgia 2010;30:543-551.
掲載日:2010/5/29

Resolvinの炎症性疼痛に対する効果
Xu Z-Z, et al. Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions.
Nat Med 2010;16:592-598.
掲載日:2010/5/29

慶應義塾大学神経内科
企画広報委員
柴田 護